The envirome and the connectome: exploring the structural noise in the human brain associated with socioeconomic deprivation

Complex cognitive functions are widely recognized to be the result of a number of brain regions working together as large-scale networks. Recently, complex network analysis has been used to characterize various structural properties of the large scale network organization of the brain. For example, the human brain has been found to have a modular architecture i.e. regions within the network form communities (modules) with more connections between regions within the community compared to regions outside it. The aim of this study was to examine the modular and overlapping modular architecture of the brain networks using complex network analysis. We also examined the association between neighborhood level deprivation and brain network structure – modularity and grey nodes. We compared network structure derived from anatomical MRI scans of 42 middle-aged neurologically healthy men from the least (LD) and the most deprived (MD) neighborhoods of Glasgow with their corresponding random networks. Cortical morphological covariance networks were constructed from the cortical thickness derived from the MRI scans of the brain. For a given modularity threshold, networks derived from the MD group showed similar number of modules compared to their corresponding random networks, while networks derived from the LD group had more modules compared to their corresponding random networks. The MD group also had fewer grey nodes – a measure of overlapping modular structure. These results suggest that apparent structural difference in brain networks may be driven by differences in cortical thicknesses between groups. This demonstrates a structural organization that is consistent with a system that is less robust and less efficient in information processing. These findings provide some evidence of the relationship between socioeconomic deprivation and brain network topology

A new algorithm for horizontal capture trajectories

An algorithm which transfers an aircraft from an initial position and heading to a final position and heading was developed for onboard synthesis of horizontal flight paths. The algorithm finds all solutions possible, and selects the one with minimum path length. Degenerate conditions in which one or more of the basic segments is missing are handled without difficulty. The solution to this problem is derived, and a FORTRAN listing of the algorithm is provided

In-depth research into rural road crashes

This report was produced under an agreement between Transport SA and the Road Accident Research Unit formed in the late 1990s. Due to various delays in the publication of this report, Transport SA has since become the Department for Transport, Energy and Infrastructure and the Road Accident Research Unit has become the Centre for Automotive Safety Research. The report describes a series of 236 rural road crashes investigated between 1 March 1998 and 29 February 2000 in South Australia. Investigations began with immediate attendance at the scene of the crash. The information collected for each crash included: photographs of the crash scene and vehicles involved, video record of the crash scene and vehicles in selected cases, examination of the road environment, a site plan of the crash scene and vehicle movements in the crash, examination and measurements of the vehicles involved, interviews with crash participants, interviews with witnesses, interviews with police, information on the official police report, information from Coroner’s reports, and injury data for the injured crash participants. The report provides an overall statistical summary of the sample of crashes investigated, followed by a detailed examination of the road infrastructure issues contributing to the crashes. This is done on the basis of crash type, with separate sections concerned with single vehicle crashes, midblock crashes and crashes at intersections. A section is also provided that examines the role of roadside hazards in the crashes.Baldock MRJ, Kloeden CN and McLean A

Computer program to calculate three-dimensional boundary layer flows over wings with wall mass transfer

A system of computer programs for calculating three dimensional transonic flow over wings, including details of the three dimensional viscous boundary layer flow, was developed. The flow is calculated in two overlapping regions: an outer potential flow region, and a boundary layer region in which the first order, three dimensional boundary layer equations are numerically solved. A consistent matching of the two solutions is achieved iteratively, thus taking into account viscous-inviscid interaction. For the inviscid outer flow calculations, the Jameson-Caughey transonic wing program FLO 27 is used, and the boundary layer calculations are performed by a finite difference boundary layer prediction program. Interface programs provide communication between the two basic flow analysis programs. Computed results are presented for the NASA F8 research wing, both with and without distributed surface suction

Squeeze-film dampers for turbomachinery stabilization

A technique for investigating the stability and damping present in centrally preloaded radially symmetric multi-mass flexible rotor bearing systems is presented. In general, one needs to find the eigenvalues of the linearized perturbation equations, though zero frequency stability maps may be found by solving as many simultaneous non-linear equations as there are dampers; and in the case of a single damper, such maps may be found directly, regardless of the number of degrees of freedom. The technique is illustrated for a simple symmetric four degree of freedom flexible rotor with an unpressurized damper. This example shows that whereas zero frequency stability maps are likely to prove to be a simple way to delineate multiple solution possibilities, they do not provide full stability information. Further, particularly for low bearing parameters, the introduction of an unpressurized squeeze film damper may promote instability in an otherwise stable system

Use of multiple discrete wall jets for delaying boundary layer separation

The effectiveness of a spanwise array of small discrete blowing nozzles in preventing separation of a turbulent boundary layer was investigated experimentally. The spacing, axial location, and momentum flux of the nozzles were varied in a systematic way, and overall performance was measured for each combination. Extensive mean velocity profiles were measured for one selected combination. Overall diffusion achieved before separation was correlated successfully with a momentum flux excess parameter, and in terms of this parameter discrete nozzles, when advantageously placed, were found to perform somewhat better than an optimally placed two-dimensional jet slot

Fuel-conservative guidance system for powered-lift aircraft

A concept for automatic terminal area guidance, comprising two modes of operation, was developed and evaluated in flight tests. In the predictive mode, fuel efficient approach trajectories are synthesized in fast time. In the tracking mode, the synthesized trajectories are reconstructed and tracked automatically. An energy rate performance model derived from the lift, drag, and propulsion system characteristics of the aircraft is used in the synthesis algorithm. The method optimizes the trajectory for the initial aircraft position and wind and temperature profiles encountered during each landing approach. The design theory and the results of simulations and flight tests using the Augmentor Wing Jet STOL Research Aircraft are described

The use of Bioceramics as root-end filling materials in periradicular surgery: a literature review

Introduction: Periradicular surgery involves the placement of a root-end filling following root-end resection, to provide an apical seal to the root canal system. Historically several materials have been used in order to achieve this seal. Recently a class of materials known as Bioceramics have been adopted. The aim of this article is to provide a review of the outcomes of periradicular surgery when Bioceramic root-end filling materials are used on human permanent teeth in comparison to “traditional” materials. Methods & results: An electronic literature search was performed in the databases of Web of Science, PubMed and Google Scholar, between 2006 and 2017, to collect clinical studies where Bioceramic materials were utilised as retrograde filling materials, and to compare such materials with traditional materials. In this search, 1 systematic review and 14 clinical studies were identified. Of these, 8 reported the success rates of retrograde Bioceramics, and 6 compared treatment outcomes of mineral trioxide aggregate (MTA) and traditional cements when used as root-end filling materials. Conclusion: Bioceramic root-end filling materials are shown to have success rates of 86.4–95.6% (over 1–5 years). Bioceramics has significantly higher success rates than amalgam, but they were statistically similar to intermediate restorative material (IRM) and Super ethoxybenzoic acid (Super EBA) when used as retrograde filling materials in apical surgery. However, it seems that the high success rates were not solely attributable to the type of the root-end filling materials. The surgical/microsurgical techniques and tooth prognostic factors may significantly affect treatment outcome

Recognizing aboriginal oral tradition through blended learning: a success story

The Aboriginal Health and Community Administration Program (AHCAP) is a certificate program developed through the partnership of the Institute for Aboriginal Health and Continuing Studies at the University of British Columbia. This paper examines factors in the program’s blended design and development which have contributed to the exceptionally high completion rate and the strongly positive responses and outcomes for widely diverse learner cohorts. Factors which appear to contribute to the program success include: 1) a holistic approach compatible with traditional Aboriginal oral traditions of teaching and learning; 2) a university partnership that taps into unique networks and capacities; 3) incorporating the 4 R’s of Aboriginal education: relevance, reciprocity, respect and responsibility generated throughout the learning and teaching, both online and face-to-face; and 4) making the program accessible to geographically and technologically diverse communities of learners.\u